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陈欣副研究员

发布时间:2022-05-20 发布单位:病原微生物研究院



 

地址:广东省广州市天河区黄埔大道西601号暨南大学成教楼七楼

邮编:510632

电话:020-85220627

邮箱:chenx@jnu.edu.cn

 

一、个人经历

1.学习经历

博士      20094-20131月    法国蒙彼利埃第一大学  分子生物学

硕士      20069-20086月    武汉大学          微生物学

2.工作经历

博士后        201412-2019年05月       中山大学肿瘤防治中心   

研究员        201310-201410月       华大基因  


 二、科研工作

1. RNA结合蛋白慢性炎症及肿瘤发生中的分子调控机制

2. 小分子药物在抗肿瘤和抗病毒感染中的用途


三、已发表的学术论文

1. Xin Chen, Jia-Xing Zhang, Jun-Hang Luo, Song Wu, Gang-Jun Yuan, Ning-Fang Ma, Yong Feng, Mu-Yan Cai, Ri-Xin Chen, Jun Lu, Li-Juan Jiang, Jie-Wei Chen, Xiao-Han Jin, Hai-Liang Liu, Wei Chen, Xin-Yuan Guan, Tie-Bang Kang, Fang-Jian Zhou, Dan Xie. CSTF2-induced shortening of the RAC1 3’UTR promotes the pathogenesis of urothelial carcinoma of the bladder. Cancer Research, 2018, Oct 15; 78(20):5848-5862. doi: 10.1158/0008-5472.

2. Xin Chen#, Ri-Xin Chen#, Wen-Su Wei#, Yong-Hong Li#, Zi-Hao Feng#, Tan Lei, Jie-Wei Chen, Gang-Jun Yuan, Si-Liang Chen, Sheng-Jie Guo, Kang-Hua Xiao, Zhuo-Wei Liu, Jun-Hang Luo, Fang-Jian Zhou*, Dan Xie*. PRMT5 circular RNA promotes metastasis of urothelial carcinoma of the bladder through sponging miR-30c to induce epithelial-mesenchymal transition. Clinical Cancer Research, 2018, Oct 10, doi: 10.1158/1078-0432. Epub ahead of print.

3. Jerome Barbier#, Xin Chen#, Gabriel Sanchez#, Muyan Cai, Marion Helsmoortel, Takuma Higuchi, Pierre Giraud, Xavier Contreras, Gangjun Yuan, Zihao Feng, Rima Nait-Saidi, Olivier Deas, Lisa Bluy, Jean-Gabriel Judde, Sylvie Rouquier, William Ritchie, Shuji Sakamoto, Dan Xie*, Rosemary Kiernan*. An NF90/NF110-Mediated Feedback Amplification Loop Regulates DICER Expression and Controls Ovarian Tumor. Cell Research, 2018, 28, 556-571.

4. Xingyong Zhang, Shusen Chen, Shaohua Jin, Xiaoxiao Lu, Lijie Li, Xin Chen#, Qinghai Shu#. Naphthalene based lab-on-a-molecule for the highly selective and sensitive detection of CN− and Ag+ in aqueous solution. Sensors and Actuators B: Chemical, 2016, 237:367-372.

5. Wen-Su We#, Xin Chen#, Li-Yi Guo#, Xiang-Dong Li, Ming-Hui Deng, Gang-Jun Yuan, Le-Ye He, Yong-Hong Li, Zhi-Lin Zhang, Li-Juan Jiang, Ri-Xin Chen, Xiao-Dan Ma, Shi Wei, Ning-Fang Ma, Zhuo-Wei Liu, Jun-Hang Luo, Fang-Jian Zhou*, Dan Xie*. TRIM65 supports bladder urothelial carcinoma cell aggressiveness by promoting ANXA2 ubiquitination and degradation. Cancer Letters. 2018, 28;435:10-22.

6. Gang-Jun Yuan#, Xin Chen#, Zhuo-Wei Liu#, Wen-Su Wei, Qing-Hai Shu, Hussein Abou-Hamdan, Li-Juan Jiang, Xiang-Dong Li, Ri-Xin Chen, Laurent Desaubry*, Fang-Jian Zhou*, Dan Xie*. Flavagline analog FL3 induces cell cycle arrest in urothelial carcinoma cell of the bladder by inhibiting the Akt/PHB interaction to activate the GADD45α pathway. J Exp Clin Cancer Res. 2018, 37:21.

7. Li Wan, Qing-Hai Shu*, Jia-Ping Zhu, Shao-Hua Jin, Na Li, Xin Chen*, Shusen Chen*. A new multifunctional Schiff-based chemosensor for mask-free fluorimetric and colorimetric sensing of F⁻ and CN⁻. Talanta, 2016, 152:39-44

8. Shi-Chao Sun, Qing-Hai Shu*, Peng-Chao Lin, Yan-Yue Li, Shao-Huua Jin, Xin Chen*, De-Quan Wang*. Triphenylamine based lab-on-a-molecule for the highly selective and sensitive detection of Zn2+ and CN− in aqueous solution. RSC Advances, 2016, 6(96)

 

四、科研项目

    主持项目:

1. Dicer的调控机制研究,法国医学基础研究青年基金(FRM),2012年,15

2. RAC1基因3’端非编码区的选择性多聚腺苷酸化在膀胱癌中的作用与临床意义, 国自然青年基金,201701-20191218

3. Prohibitin靶向化合物FL3抑制膀胱癌增殖的机制研究,省自然博士启动基金,201601-20181210

    参与项目:

1. RNA甲基化转移酶NSUN2对膀胱癌发生发展的调控机制研究,国自然面上基金,201701-20201260万元

2. Circ-PRMT5调控膀胱癌上皮间质转化的作用及机制研究,国自然面上基金,201801-20211255万元

 

五、发明专利

1. 肌张力障碍VPS16基因的检测引物、方法和试剂盒,已授权,2018

 

、荣誉奖励

        法国国家科学院(CNRS)博士奖学金

 

、学术兼职

        广东省抗癌协会肿瘤转移专委会委员