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发布时间:2020-05-27 发布单位:病原微生物研究院


地址:广东省广州市天河区黄埔大道西601号暨南大学成交楼7

邮编:510632

电话:020-85220949

邮箱:2019268wp@stu.jnu.edu.cn


个人经历

20197-至今    暨南大学,病原微生物研究院,博士后

20129-20196月 武汉大学,生命科学学院,微生物学,博士

20089-20126月 长江大学,生命科学学院,生物技术,学士


二、科研工作

  主要研究方向(1)先天性免疫中NLRP3炎症小体调控的机制,特别是宿主负调控NLRP3小体激活的具体分子机制(2)研究NLRP3炎症小体与各种疾病之间的相互关系(3)研究寨卡病毒在睾丸中的致病机理;(4)新型溶瘤腺病毒的改造和构建

  科研成果情况:发表SCI论文10篇,其中包括PLoS PathogensThe FASEB Journal, Journal of ImmunologyJournal of Virology等杂志


学术论文

1. Wan P#, Zhang Q#, Liu WY#, Jia YL, Ai S, Wang TC, Wang WB, Pan P, Yang G, Xiang Q, Huang SY, Yang QY, Zhang W, Liu F, Tan QP, Zhang W, Wu KL, Liu YL* and Wu JG*. Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation. The FASEB Journal 2019; 33(4):5793-5807. IF:5.391Top期刊

2. Wang WB#, Xiao F#, Wan P, Pan P, Zhang YC, Liu F, Wu KL, Liu YL* and Wu JG*.  EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex. PLoS Pathogens 2017; 13(1): e1006123.IF:6.463 Top期刊

3. Pan P#, Zhang Q#, Liu WY#, Wang WB, Lao ZZ, Zhang W, Shen MM, Wan P, Xiao F, Liu F, Zhang W, Tan QP, Liu XH, Wu KL, Liu YL*, Li G* and Wu JG*. Dengue Virus M Protein Promotes NLRP3 Inflammasome Activation To Induce Vascular Leakage in Mice. Journal of Virology 2019; 93(21):e00996-19.IF:4.324Top期刊

4. Shao LY#, Liu Y#, Wang WB, Li AX, Wan P, Liu WY, Shereen MA, Liu F, Zhang W, Tan QP, Wu KL, Liu YL* and Wu JG*. (2020). SUMO1 SUMOylates and SENP3 deSUMOylates NLRP3 to orchestrate the inflammasome activation. The FASEB Journal 2020; 34(1):1497–1515.IF:5.391Top期刊

5. Wang WB#, Hu DW#, Wu CF, Feng YQ, Li AX, Liu WY, Wang YC, Chen KL, Tian MF, Xiao F, Zhang Q, Shereen MA, Chen WJ, Pan P, Wan P, Wu KL*, Wu JG*. STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection. PLoS Pathogens 2020; 16(3):e1008335. IF:6.463Top期刊

6. Ge ML#, Luo Z#, Qiao Z#, Zhou Y, Cheng X, Geng QB, Cai YY, Wan P, Xiong Y, Liu F, Wu KL*, Liu YL* and Wu JG*. HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress. Journal of Immunology 2017; 199, 3280-3292.IF:4.718]Top期刊

7. Yang Q#, Zhang Q#, Zhang XW#, You L, Wang WB, Liu WY, Han Y, Ma CQ, Xu W, Chen JB, Yang H, Wan P, Zhou Y, Liu Y, Wu KL, Yang ZW* and Wu JG*. HoxA10 Facilitates SHP-1-catalized Dephosphorylation of p38 MAPK/STAT3 to Repress Hepatitis B Virus Replication. Journal of Virology 2019; 93(7).IF:4.324Top期刊

8. Yu Y, Wan P, Cao YH, Zhang W, Chen JB, Tan L, Wang Y, Sun ZC, Zhang Q, Wan YS, Zhu Y, Liu F, Wu KL*, Liu YL* and Wu JG*. Hepatitis B Virus e Antigen Activates the Suppressor of Cytokine Signaling 2 to Repress Interferon Action. Scientific Reports 2017; 7(1):1729.[IF:4.011

9. Zhang W, Han DJ, Wan P, Pan P, Cao YH, Liu YL*,Wu KL* and Wu JG*. ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation. Scientific Reports 2016; 6, 34543.[IF:4.011

10. Pan P#, Zhang Q#, Liu WY#, Wang WB, Yu ZY, Lao ZZ, Zhang W, Shen MM, Wan P, Xiao F, Shereen MA, Zhang W, Tan QP, Liu YT, Liu XH, Wu KL, Liu YL*, Li G* and Wu JG*. Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage. Frontiers in Microbiology 2019; 10:2637.IF:4.259

 

获奖情况

 2019年,武汉大学,“研究生学术创新奖”二等奖

 2019年,武汉大学病毒学国家重点实验室,“吉凯病毒学青年创新奖”二等奖。