地址：广东省广州市天河区黄埔大道西601号暨南大学成教楼七楼
邮编：510632
电话：020-85220949
一、个人经历
1. 学习经历
2009/9 - 2013/7，河南师范大学，生命科学学院，生物科学，本科
2013/9 - 2019/12，武汉大学，生命科学学院，病毒学国家重点实验室，博士
2. 工作经历
2019/11—2021/11，暨南大学，附属第一医院/病原微生物研究院，博士后
2022/01-2022/10，佛山病原微生物研究院，研究员
2022/10-至今，暨南大学，附属第一医院，第四层次引进人才
二、科学研究
研究方向为病毒感染激活炎症导致相关疾病的分子机制、抗病毒靶点的筛选和干细胞以及免疫细胞的临床转化研究等。共发表学术论文20余篇，其中以第一作者（含共同第一作者）或通讯作用论文先后在Journal of Virology, Frontiers in Microbiology, Plos Pathogens, Nature Communications, Antiviral research，Applied Materials Today，Signal Transduction and Targeted Therapy，Analytica Chimica Acta等权威杂志发表。论文累计被他人引用次数超过2000多次，H指数15；获得国家发明专利授权5项；主持承担各级科研项目7项，包含中国国家自然科学青年基金，中国博士后科学基金（特别资助）和面上项目等，参与国家级科研项目5项。
三、学术论文
1. Yuan W#, Xiao K#, Liu X, Lai Y, Luo F, Xiao W, Wu J, Pan P*, Li Y*, Xiao H*. (2023) A programmable DNA nanodevice for colorimetric detection of DNA methyltransferase activity using functionalized hemin/G-quadruplex DNAzyme. Analytica Chimica Acta, 1273:341559. IF:6.2 中科院1区 Top
2. Pan, P#*., Ge, W#., Lei, Z#., Luo, W#., Liu, Y., Guan, Z., Chen, L., Yu, Z., Shen, M., Hu, D., Xiang, Q., Wang, W., Wan, P., Tian, M., Yu, Y., Luo, Z., Chen, X., Xiao, H., Zhang, Q., Liang, X., Chen, X*., Li, Y*., & Wu, J. (2023). SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication. Signal transduction and targeted therapy, 8(1), 194. IF:38.104 中科院1区 Top
3. Fan, Y#., Zhang, Q#., Zhang, W#., Lai, Y., Long, H., Huang, H., Zhan, S., Liu, X., Lai, J., Zhang, Z., Pan, P*., Su, Z*., & Li, G*. (2023). Inhibitory effects of Patchouli alcohol on the early lifecycle stages of influenza A virus. Frontiers in microbiology. 13:938868. IF:6.604 中科院2区 Top
4. Lei, Z#., Zhu, L#., Pan, P#., Ruan, Z., Gu, Y., Xia, X., Wang, S., Ge, W., Yao, Y., Luo, F., Xiao, H., Guo, J., Ding, Q., Yin, Z., Li, Y., Luo, Z., Zhang, Q*., Chen, X*., & Wu, J*. (2023). A vaccine delivery system promotes strong immune responses against SARS-CoV-2 variants. Journal of medical virology, 10.1002/jmv.28475. IF:20.693 中科院3区
5. Pan, P#., Shen, M#., Yu, Z#., Ge, W., Chen, K., Tian, M., Xiao, F., Wang, Z., Wang, J., Jia, Y., Wang, W., Wan, P., Zhang, J., Chen, W., Lei, Z., Chen, X., Luo, Z., Zhang, Q., Xu, M., Li, G*., Li, Y*., & Wu, J*. (2021). SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nature communications, 12(1), 4664. IF:17.694 中科院1区 Top
6. Li Y#, Huang Y#, Pan P#, Che X, Zhang Y, Zhang Y, Amal A, Li X, Niu W, Luo N, Zhang W, Gao D, Tan Q, Zhang Q, Xing X*, Luo Z*, Wu J*. 2021. Sericin and sericin-derived peptide alleviate viral pathogenesis in mice though inhibiting lactate production and facilitating antiviral response. Applied Materials Today 25:101256 IF:10.041 中科院1区 Top
7. Pan, P#., Li, G#., Shen, M., Yu, Z., Ge, W., Lao, Z., Fan, Y., Chen, K., Ding, Z., Wang, W., Wan, P., Shereen, M. A., Luo, Z., Chen, X., Zhang, Q., Lin, L*., & Wu, J*. (2021). DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction. PLoS pathogens, 17(7), e1008603. IF:7.467 中科院1区 Top
8. Chen, Y#., Li, Z#., Pan, P.#, Lao, Z., Xu, J., Li, Z., Zhan, S., Liu, X., Wu, Y*., Wang, W*., Li, G*. (2021). Cinnamic acid inhibits Zika virus by inhibiting RdRp activity. Antiviral research, 192, 105117. IF:10.103 中科院2区
9. Pan, P#., Zhang, Q#., Liu, W#., Wang, W., Lao, Z., Zhang, W., Shen, M., Wan, P., Xiao, F., Liu, F., Zhang, W., Tan, Q., Liu, X., Wu, K., Liu, Y*., Li, G*., & Wu, J*. (2019). Dengue Virus M Protein Promotes NLRP3 Inflammasome Activation To Induce Vascular Leakage in Mice. Journal of virology, 93(21), e00996-19. IF:6.549 中科院2区 Top
10. Pan, P#., Zhang, Q#., Liu, W#., Wang, W., Yu, Z., Lao, Z., Zhang, W., Shen, M., Wan, P., Xiao, F., Shereen, M. A., Zhang, W., Tan, Q., Liu, Y., Liu, X., Wu, K., Liu, Y*., Li, G*., & Wu, J*. (2019). Dengue Virus Infection Activates Interleukin-1β to Induce Tissue Injury and Vascular Leakage. Frontiers in microbiology, 10, 2637. IF:6.604 中科院2区 Top
11. Li, G#., Pan, P#., He, Q., Kong, X., Wu, K., Zhang, W., Liu, Y., Huang, H., Liu, J., Zhang, Z., Wu, D., Lai, X., Liu, X*., & Wu, J*. (2017). Molecular epidemiology demonstrates that imported and local strains circulated during the 2014 dengue outbreak in Guangzhou, China. Virologica Sinica, 32(1), 63–72. IF:6.947 中科院2区
12. Ruan, Z#., Liang, Y#., Chen, Z., Yin, J., Li, C., Pan, P., Zhang, Q., Wu, J*., & Luo, Z*. (2022). Enterovirus 71 non-structural protein 3A hijacks vacuolar protein sorting 25 to boost exosome biogenesis to facilitate viral replication. Frontiers in microbiology, 13, 1024899. IF:6.604 中科院2区 Top
13. Wan, P., Zhang, S., Ruan, Z., Liu, X., Yang, G., Jia, Y., Li, Y., Pan, P., Wang, W., Li, G., Chen, X., Liu, Z., Zhang, Q., Luo, Z., & Wu, J. (2022). AP-1 signaling pathway promotes pro-IL-1β transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection. Virulence, 13(1), 502–513. IF:5.428 中科院2区
14. Wan, P., Yang, G., Zhang, S., Zhang, Y., Jia, Y., Che, X., Luo, Z., Pan, P., Li, G., Chen, X., Zhang, Q., Zhang, W., Tan, Q., Li, Y., & Wu, J. (2022). ASB17 Facilitates the Burst of LPS-Induced Inflammation Through Maintaining TRAF6 Stability. Frontiers in cellular and infection microbiology, 12, 759077. IF:6.073 中科院2区
15. Lai, J., Meng, Q. F., Tian, M., Zhuang, X., Pan, P., Du, L., Deng, L., Tang, J., Jin, N., & Rao, L. (2022). A decoy microrobot that removes SARS-CoV-2 and its variants in wastewater. Cell reports. Physical science, 3(10), 101061. IF:7.832
16. Wang, W., Chen, J., Hu, D., Pan, P., Liang, L., Wu, W., Tang, Y., Huang, X. R., Yu, X., Wu, J., & Lan, H. Y. (2021). SARS-CoV-2 N Protein Induces Acute Kidney Injury via Smad3-Dependent G1 Cell Cycle Arrest Mechanism. Advanced science, e2103248. IF:17.521 中科院1区 Top
17. Luo, Z#., Zhu, C#., Ruan, Z., Cui, X., Shereen, M. A., Pan, P., Huang, J., Wang, F., Su, H., Xia, Y*., & Wu, J*. (2021). Longitudinal Characterization of Cytokine Overproduction: A Case Report in Critically Ill COVID-19 Patients With Hyperinflammation in Bronchoalveolar Lavage. Frontiers in medicine, 8, 690523. IF:5.093 中科院3区
18. Huang, S., Wan, P., Huang, S., Liu, S., Xiang, Q., Yang, G., Shereen, M. A., Pan, P., Wang, J., Liu, W., Wu, K., & Wu, J*. (2021). The APC10 subunit of the anaphase-promoting complex/cyclosome orchestrates NLRP3 inflammasome activation during the cell cycle. FEBS letters, 595(19), 2463–2478. IF:4.124 中科院3区
19. Tian, M., Liu, W., Li, X., Zhao, P., Shereen, M. A., Zhu, C., Huang, S., Liu, S., Yu, X., Yue, M., Pan, P., Wang, W., Li, Y., Chen, X., Wu, K., Luo, Z., Zhang, Q., & Wu, J. (2021). HIF-1α promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19. Signal transduction and targeted therapy, 6(1), 308. IF:38.104 中科院1区 Top
20. Chen, K#., Xiao, F#., Hu, D., Ge, W., Tian, M., Wang, W., Pan, P., Wu, K., & Wu, J*. (2020). SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β Production. Viruses, 13(1), 47. IF:5.048 中科院2区
21. Wang, W., Hu, D., Feng, Y., Wu, C., Song, Y., Liu, W., Li, A., Wang, Y., Chen, K., Tian, M., Xiao, F., Zhang, Q., Chen, W., Pan, P., Wan, P., Liu, Y., Lan, H*., Wu, K*., & Wu, J*. (2020). Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome. BMC biology, 18(1), 182. IF:7.431 中科院2区 Top
22. Rao, L., Xia, S., Xu, W., Tian, R., Yu, G., Gu, C., Pan, P., Meng, Q. F., Cai, X., Qu, D., Lu, L., Xie, Y., Jiang, S., & Chen, X. (2020). Decoy nanoparticles protect against COVID-19 by concurrently adsorbing viruses and inflammatory cytokines. Proceedings of the National Academy of Sciences of the United States of America, 117(44), 27141–27147. IF:9.58 中科院1区 Top
23. Wang, W#., Hu, D#., Wu, C., Feng, Y., Li, A., Liu, W., Wang, Y., Chen, K., Tian, M., Xiao, F., Zhang, Q., Shereen, M. A., Chen, W., Pan, P., Wan, P., Wu, K., & Wu, J*. (2020). STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection. PLoS pathogens, 16(3), e1008335. IF:7.467 中科院1区 Top
24. Li, G., Fan, Y., Lai, Y., Han, T., Li, Z., Zhou, P., Pan, P., Wang, W., Hu, D., Liu, X., Zhang, Q., & Wu, J. (2020). Coronavirus infections and immune responses. Journal of medical virology, 92(4), 424–432. IF:20.693 中科院3区
25. Wan, P., Zhang, Q., Liu, W., Jia, Y., Ai, S., Wang, T., Wang, W., Pan, P., Yang, G., Xiang, Q., Huang, S., Yang, Q., Zhang, W., Liu, F., Tan, Q., Zhang, W., Wu, K., Liu, Y., & Wu, J. (2019). Cullin1 binds and promotes NLRP3 ubiquitination to repress systematic inflammasome activation. FASEB journal, 33(4), 5793–5807. IF:5.129 中科院2区 Top
26. Wang, W#., Li, G#., De Wu#, Luo, Z#., Pan, P., Tian, M., Wang, Y., Xiao, F., Li, A., Wu, K., Liu, X., Rao, L., Liu, F*., Liu, Y*., & Wu, J*. (2018). Zika virus infection induces host inflammatory responses by facilitating NLRP3 inflammasome assembly and interleukin-1β secretion. Nature communications, 9(1), 106. IF:17.694 中科院1区 Top
27. Wang, W#., Xiao, F#., Wan, P., Pan, P., Zhang, Y., Liu, F., Wu, K., Liu, Y*., & Wu, J*. (2017). EV71 3D Protein Binds with NLRP3 and Enhances the Assembly of Inflammasome Complex. PLoS pathogens, 13(1), e1006123. IF:7.467 中科院1区 Top
28. Liao, F., Chen, H., Xie, J., Zhan, S., Pan, P., Lao, Z., Fan, Y., Lin, L., Lai, Y., Lin, S., Wu, J., Liu, X., & Li, G*. (2019). Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018. PloS one, 14(11), e0224676. IF:3.752 中科院3区
29.Zhang, W., Han, D., Wan, P., Pan, P., Cao, Y., Liu, Y., Wu, K*., & Wu, J*. (2016). ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation. Scientific reports, 6, 34543. IF:4.38 中科院3区
四、科研项目
1. 中国博士后科学基金会，第68批面上项目，2020M683177，基质金属蛋白酶9在登革病毒感染诱导血管渗漏中的分子机制研究，2020-08至2022-08，8万元，结题，主持
2. 中国博士后科学基金会，新冠肺炎疫情防控专项资助（特别资助），2020T130046ZX，
新型冠状病毒通过激活NLRP3炎症小体诱导肺损伤的分子机制研究，2020-05至2022-05，18万元，结题，主持
3.暨南大学中央高校基本科研业务费青年基金项目，寨卡病毒NS4A通过激活凋亡通路从而促进病毒穿过血脑屏障的分子机制研究，9万元，结题，主持。
4. 病毒学国家重点实验室2021年度开放课题，2021KF003，登革病毒NS1蛋白诱导血管渗漏分子机制研究，2021-03至2023-02，6万元，在研，主持。
5.国家自然科学基金委员会, 青年科学基金项目, 32200117, 新冠病毒N蛋白通过去泛素化MCL-1抑制细胞凋亡的机制研究, 2023-01-01 至 2025-12-31, 30万元, 在研, 主持
6.广东省病毒学重点实验室2022年开放课题，2022KF003，新冠病毒N蛋白抑制细胞凋亡的分子机制研究，2023-01至2023-12, 3万元，在研，主持。
7.暨南大学附属第一医院第四层次引进人才科研启动经费，基于新冠病毒结构蛋白和宿主蛋白间的相关作用探究新冠病毒感染导致疾病的分子机制研究，2023-01至2023-12, 50万元，在研，主持
五、发明专利授权
1. 潘攀；申苗苗；陈俊；葛威威；李永奎。S63845在制备抗新冠病毒感染药物中的应用。授权公告日2023.04.23，授权专利号：2022114265498。
2. 吴建国; 邬开朗; 马春强; 潘攀; 刘映乐; 刘芳。骨硬化病相关跨膜蛋白在治疗或预防EV71 感染药物中的应用。 授权公告日：2019.09.24， 授权专利号： ZL201610216836.4。
3. 吴建国; 李永奎; 黄颖; 邢曦雯; 罗震; 潘攀; 张业顺。丝胶蛋白、提取方法、作为细胞抗病毒免疫增强剂和应用。授权公告日： 2020.09.14, 授权专利号： CN202010961734.1。
4. 李永奎; 吴建国; 罗震; 邢曦雯; 潘攀。可介导生物大分子透皮吸收的组合剂、制备方法及应用。授权公告日：2021.04.08，授权专利号：ZL202110377048.4。