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张其威教授

发布时间:2022-09-25 发布单位:病原微生物研究院


 


暨南大学病原微生物研究院副院长/党支部书记

广东省病毒学重点实验室副主任

广东特支计划青年拔尖人才

广东省高校优秀青年教师

广州市珠江科技新星

博士生/硕士生导师


 

地址:广东省广州市天河区黄埔大道西601号暨南大学梁仲景楼七楼

邮编:510632

电话:020-85220949

邮箱:zhangqw@jnu.edu.cn


Google Scholar: https://scholar.google.com/citations?user=aV89laYAAAAJ

  

一、个人经历

1. 学习经历

2008.08-2010.10:香港大学李嘉诚医学院,微生物系 博士后

2007.08-2008.07:香港大学李嘉诚医学院,微生物系  Research Assistant

2002.09-2007.06武汉大学病毒学国家重点实验室,病毒学博士

1998.09-2002.06武汉大学生命科学学院,微生物学本科

2. 工作经历

(1)暨南大学病原微生物研究院/广东省病毒学重点实验室,高层次引进人才,教授,博导,党支部书记,副院长

(2)哈佛大学医学院,访问学者

(3)南方医科大学公共卫生学院,病原生物学专业教授


  

二、个人简介

广东省病毒学重点实验室/暨南大学病原微生物研究院教授、博导、副院长、党支部书记,广东省病毒学重点实验室副主任,武汉大学微生物学学士、病毒学国家重点实验室博士、香港大学医学院微生物系博士后、哈佛大学医学院访问学者、广东特支计划青年拔尖人才、广东省高校优秀青年教师、广州市珠江科技新星,主要研究方向包括呼吸道病毒的分子进化、致病机制、新型腺病毒载体、疫苗、抗病毒药物等;在呼吸道腺病毒的基础和应用基础研究方向取得了一定成果,推动了我国腺病毒研究的快速发展。

承担国家重点研发计划课题1项、国家自然科学基金4项,省市级项目8项;在New England Journal of MedicineNature CommunicationsSignal Transduct Target Ther 3篇),Emerging Infectious DiseasesJournal of Virology5篇),Vaccine2篇),Emerging Microbes and Infections2篇),Frontiers in Immunology等国际学术刊物上发表60多篇研究论文,引用4000多次(高被引论文5篇),h指数27,参编专著2;曾获得武汉市科技成果奖、深圳市科协优秀自然科学学术论文奖,发明专利授权3项。

担任中国微生物学会病毒学专业委会委员,医学微生物学与免疫学专委会青委,NCBI人类腺病毒研究组委员,中国疫苗行业协会疫苗学教育专委会委员,教育部学位与研究生教育发展中心全国研究生教育评估监测专家,国家人才项目评审专家,中华中医医药学会儿童医学健康中西医协作创新平台专家,广东省应急管理专家委员会委员,2020年广东省战专家组成员,中国腺病毒研究协作组发起人和负责人;担任第13届国际腺病毒大会分会主持人,首届全国腺病毒学术研讨会大会共同主席,第四届全国病毒学青年学者学术研讨会大会共同主席;Military Medical ResearchVirologica SinicaFrontiers in MicrobiologymBio Editor国家大学生创新创业训练项目、广东省攀登计划大学生科技创新项目、挑战杯大学生科技竞赛、广东省大学生预防医学实验技能大赛的指导教师。广东省精品开放课程《走进微生物世界》主讲人,曾担任八年制医学生导师,《发展中国家传染病防治技术培训班》主讲教师发表2篇教学研究论文。 

招聘微生物学、分子生物学、流行病学、兽医、药学等研究方向的硕士生、博士生、博士后、科研助理多名,有意者随时联系zhangqw@jnu.edu.cn   

研究方向: 

1. 病毒分子进化:综合各种基因组学方法,研究病毒在流行传播过程中基因组的突变、重组规律和流行趋势,为疾病防控策略的制定提供重要依据。

2. 病毒感染致病机制研究:通过细胞、免疫、分子层面研究,阐明不同型别呼吸道病毒感染引起重症的机制,为抗病毒药物研发提供重要参考。

3. 抗病毒药物研究:筛选鉴定高效低毒广谱的抗呼吸道病毒的小分子药物,以解决目前临床抗病毒药物面临的各种问题。

4. 呼吸道病毒疫苗研究:开发新型的呼吸道病毒mRNA疫苗和腺病毒载体疫苗,达到通用、广谱、长效的预防效果。

5. 腺病毒载体研究:开发新型的猴腺病毒载体,以替代目前所用的人腺病毒载体,用于病毒疫苗和基因治疗。

6. 动物病毒跨种传播机制研究:研究动物病毒跨种传播感染人体的分子机制,为人兽共患病的防控提供理论参考。

 My research interests are the genomics, epidemiology, novel vectors, antivirals and vaccines for human adenoviruses (AdVs) and SARS-CoV-2, etc.

  1. Recently, more and more human acute respiratory disease outbreaks caused by AdV have emerged in schools, families and military. We are developing effective antiviral drugs and vaccine candidates using new strategies and optimal animal models.

 2. Analysis of whole-genome sequences for these emergent AdVs and identification of the homologous recombination and transmission mechanism during adenovirus evolution.

 3. The cross-species transmission (CST) of animal AdVs is a potential threat to human health and animal adenovirus vector development. The study of CST of AdVs in simians provides a scientific basis for the prevention and control of adenovirus diseases as well as for the novel simian AdV vector development.  

4. Research on the pathogenic mechanism of viral infection: Through research at the cellular, immune and molecular levels, the mechanism of severe illness caused by different types of respiratory virus infection will be elucidated, and an important reference will be provided for the research and development of antiviral drugs.

三、主持的科研项目

(1)中央高校基本科研业务费交叉学科培育专项:广谱抗人呼吸道腺病毒感染的中药小分子化合物研究(21622101),2022.01-2023.12

(2)广东省自然科学基金面上项目:大黄素和黄连素抗人3471455型腺病毒的研究(2022A1515011190),2022.01-2024.12

(3)广东省自然科学基金面上项目:广谱抗人呼吸道腺病毒RNAi药物的研究2021A1515010788),2021.01-2023.12

(4)国家重点研发计划:国际新发病毒变异变迁规律及靶点模型研究(2018YFE0204503, 2019.08-2022.12

(5)国家自然科学基金面上项目:人腺病毒和猴腺病毒的跨物种传播与基因组重组机制的研究32170139),2022.01-2025.12

(6)国家自然科学基金面上项目:人腺病毒免疫抑制小鼠感染模型的建立及其致病机制的研究31570155),2016.01-2019.12

(7)国家自然科学基金面上项目:我国新发现的1455型腺病毒的生物学特性与基因组重组机制的研究31370199),2014.01-2017.12

(8)国家自然科学基金青年项目:3型、7型腺病毒双价减毒重组疫苗候选株的构建及免疫原性研究31100133),2012.01-2014.12

(9)广东省自然科学基金团队项目,子课题:HIV潜伏激活的分子机制与新型靶向性潜伏激活剂的研究(2018B0303120102018.05.01-2023.4.30

10)广州市健康医疗协同创新重大专项 病毒感染重症救治的特异性被动免疫应用研究及腺病毒单克隆抗体药物研发”(201803040004)子课题, 2018.4-2021.03

11)广州市健康医疗协同创新重大专项 呼吸道重要传染病疫苗的制备及临床研究”(201803040007)子课题, 2018.04-2021.03

12)广州市健康医疗协同创新重大专项呼吸道新发突发及重大传染病综合防诊治子课题:腺病毒流行病学特征研究201400000002),2014.03-2017.02

13)广东省自然科学基金自由申请项目:347型腺病毒三价减毒重组疫苗候选株的构建及免疫原性研究S2012010009261),2012.10-2014.10

14)香港大学博士后基金:Construction and Characterization of a Full-Length Infectious Molecular Clone from the HIV Type 1 CRF08_BC Isolated in China. 2008.08-2010.10

四、授权专利

1. 《一种病毒基因组核酸快速提取试剂盒及其使用方法》,ZL 202110657003.2

2. 《一种人3型腺病毒复制缺陷型重组病毒、构建方法及应用》,ZL202010055543.9

3. 《人呼吸道合胞病毒荧光定量PCR试剂盒及其检测方法》,ZL200310111382.7

 五、著作专著

美国微生物学会《Clinical Virology》的中文版(第26腺病毒),科学出版社,2012.

Molecular Medical Microbiology 》(负责腺病毒章节),2023.

六、荣誉奖励与指导学生 

(1)广东特支计划青年拔尖人才

(2)广东省高校优秀青年教师

(3)广州市珠江科技新星

(4)广东省千百十工程培养对象

(5)武汉市科学技术成果奖:RSV荧光定量PCR检测方法的建立及其初步应用

(6)深圳市科协优秀自然科学学术论文奖

(7)广东省大学生预防医学实验技能大赛二等奖指导教师

(8)广东省攀登计划大学生科技创新自然科学类资助项目指导教师

(9)国家级/省级大学生创新创业训练计划项目指导教师

(10)“挑战杯大学生课外学术科技作品竞赛指导教师

七、学术兼职与服务 

(1)中国微生物学会病毒学专业委员会委员

(2)中国微生物学会病毒学专业委员会:青年委员

(3)中国微生物学会医学微生物学与免疫学专委会:青年委员

(4)广东省遗传学会青年委员

(5)广东省南山医药创新研究院特聘研究员

(6)国际腺病毒大会学术委员会委员

(7)13届国际腺病毒大会分会主持人

(8)NCBI人类腺病毒研究组委员(亚洲代表)

(9)中国腺病毒研究协作组发起人和负责人

(10)“首届全国腺病毒学术研讨会大会共同主席

(11)“第四届全国病毒学青年学者学术研讨会大会共同主席

(12) 广东省应急管理专家委员会委员

(13) 教育部学位与研究生教育发展中心全国研究生教育评估监测专家

(14) 2020年广东省战专家组成员

(15) 中华中医医药学会儿童医学健康中西医协作创新平台专家

(16) Military Medical Research/Frontiers in Microbiology/Virologica Sinica/mBio Editor.

(20) 论文审稿人:Lancet Infectious Diseases, Signal Transduct Target Ther, Cell Discovery, Med, Emerging Infectious Diseases, mBio, Antimicrobial Agents and Chemotherapy, Cladistics, Microbiology Spectrum, Antiviral Research, Antiviral Therapy, Vaccine, Virulence, Virus Evolution, Viruses, Viral ImmunologyHuman Vaccines & Immunotherapeutics, Clinical Epidemiology, International Journal of Biological Sciences, Journal of Medical Virology, Journal of Visualized Experiments, Cell & Bioscience, Frontiers in Cellular and Infection Microbiology, Frontiers in Microbiology, Frontiers in Molecular Biosciences, Virologica Sinica, Microbiology and Immunology, Scientific Reports, PLoS ONE, Jornal de Pediatria, BMC Infectious Diseases, BMC Res Notes, Process Biochemistry, BMJ OPEN, Immunity, Inflammation and Disease, 中华实验和临床病毒学杂志, 病毒学报,中国科学, etc.

八、学术论文*通讯作者)

(1) Qiwei Zhang*, Donald Seto. Chimpanzee Adenovirus Vector Ebola Vaccine--Preliminary Report. New England Journal of Medicine. 2015, 373(8): 775-776. (医学一区,Top期刊IF: 176.079) http://www.smu.edu.cn/info/1139/1400.htm 

 

(2) Junxian Ou, Wendong Lan, Xiaowei Wu, Tie Zhao, Biyan Duan, Peipei Yang, Yi Ren, Lulu Quan, Wei Zhao, Donald Seto, James Chodosh, Zhen Luo, Jianguo Wu*, and Qiwei Zhang*Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events. Signal Transduction and Targeted Therapy 2022 April 26; 7(1): 138.  (医学一区,Top期刊,IF: 38.104, 高被引论文) https://mp.weixin.qq.com/s/CtYJeXoTf4_1sYCyz-90Fw  

 

(3) Junxian Ou, Zhonghua Zhou, Ruixue Dai, Jing Zhang, Shan Zhao, Xiaowei Wu, Wendong Lan, Yi Ren, Lilian Cui, Qiaoshuai Lan, Lu Lu, Donald Seto, James Chodosh, Jianguo Wu, Gong Zhang*, Qiwei Zhang*. V367F mutation in SARS-CoV-2 spike RBD emerging during the early transmission phase enhances viral infectivity through increased human ACE2 receptor binding affinity. Journal of Virology, 2021, 95(16):e0061721. Doi:10.1128/JVI.00617-21. (病毒学一区,Top期刊IF: 6.549 高被引论文https://mp.weixin.qq.com/s/TEqgtrqDLT3egH0KhF2zsQ 

 

(4) Junxian Ou, Jianguo Wu and Qiwei Zhang*. Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants. Signal Transduction and Targeted Therapy.  2022, 7(1): 322. Signal Transduction and Targeted Therapy 2022 April 26; 7(1): 138. (医学一区,Top期刊IF: 38.104) https://www.nature.com/articles/s41392-022-01179-5 

 

(5) Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo*, Qiwei Zhang* and Jianguo Wu*. HIF-1alpha promotes SARS-CoV-2 infection and aggravates inflammatory responses to COVID-19. Signal Transduct Target Ther. 2021, 6(1): 308. (医学一区,Top期刊,IF: 38.104) https://iommb.jnu.edu.cn/2021/0820/c16001a641843/page.htm 

 

(6) Xiaowei Wu#, Jing Zhang#, Wendong Lan#, Lulu Quan, Junxian Ou, Wei Zhao, Jianguo Wu, Patrick C. Y. Woo, Donald Seto* and Qiwei Zhang*. Molecular Typing and Rapid Identification of Human Adenoviruses Associated With Respiratory Diseases Using Universal PCR and Sequencing Primers for the Three Major Capsid Genes: Penton Base, Hexon, and Fiber. Frontiers in Microbiology.  2022, 13: 911694. (生物学二区,Top期刊) https://mp.weixin.qq.com/s/OHSCIf3SAVT7pVWZGTcmrg 

 

(7) Pan Pan, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Keli Chen, Mingfu Tian, Feng Xiao, Zhenwei Wang, Jun Wang, Yaling Jia, Wenbiao Wang, Pin Wan, Jing Zhang, Weijie Chen, Zhiwei Lei, Xin Chen, Zhen Luo, Qiwei Zhang, Meng Xu, Geng Li, Yongkui Li and Jianguo Wu. SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation. Nature Communications. 2021, 12(1): 4664. (综合一区,IF: 17.694Top期刊 高被引论文)

 

(8) Zhixin Liu, Xiao Xiao, Xiuli Wei, Jian Li, Jing Yang, Huabing Tan, Jianyong Zhu, Qiwei Zhang, Jianguo Wu and Long Liu. Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. J Med Virol. 2020, 92(6): 595-601. IF20.693,高被引论文

 

(9) G. Li, Y. Fan, Y. Lai, T. Han, Z. Li, P. Zhou, P. Pan, W. Wang, D. Hu, X. Liu, Q. Zhang and J. Wu. Coronavirus Infections and Immune Responses. J Med Virol.  2020, 92(4): 424-432. IF20.693, 高被引论文

 

(10) Pan Pan, Geng Li, Miaomiao Shen, Zhenyang Yu, Weiwei Ge, Zizhao Lao, Yaohua Fan, Keli Chen, Zhihao Ding, Wenbiao Wang, Pin Wan, Muhammad Adnan Shereen, Zhen Luo, Xulin Chen, Qiwei Zhang, Luping Lin and Jianguo Wu. DENV NS1 and MMP-9 cooperate to induce vascular leakage by altering endothelial cell adhesion and tight junction. PLOS Pathogens.  2021, 17(7): e1008603. (医学一区,Top期刊)

 

(11) Shuping Jing#, Jing Zhang#, Mengchan Cao, Minhong Liu, Yuqian Yan, Shan Zhao, Na Cao, Junxian Ou, Kui Ma, Xiangran Cai, Jianguo Wu, Ya-Fang Mei, and Qiwei Zhang*. Household Transmission of Human Adenovirus Type 55 in Case of Fatal Acute Respiratory Disease. Emerging Infectious Diseases. 2019, 25(9): 1754-1756 (医学一区,Top刊,IF: 16.126)

          http://blog.sciencenet.cn/home.php?mod=space&uid=51164&do=blog&id=1194147

 

(12) Jing Zhao#, Shan Zhao#, Junxian Ou, Jing Zhang, Wendong Lan, Wenyi Guan, Xiaowei Wu, Yuqian Yan, Wei Zhao, Jianguo Wu, James Chodosh and Qiwei Zhang*. COVID-19: Coronavirus Vaccine Development Updates. Frontiers in Immunology.  2020, 11(3435): 602256. (医学二区,Top期刊 IF 8.786,引用>80次)   http://mrw.so/5VXG6N 

 

(13) Zhonghua Zhou, Ziyi Yang, Junxian Ou, Hong Zhang, Qiwei Zhang*, Ming Dong* and Gong Zhang*. Temperature Dependence of the SARS-CoV-2 affinity to human ACE2 determines COVID-19 progression and clinical outcome. Computational and Structural Biotechnology Journal.  202119:161-167.(生物学二区,IF7.271)     

      http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2021-01/06/content_460576.htm?div=-1

      http://stdaily.com/index/kejixinwen/2020-12/28/content_1065892.shtml

      https://enapp.chinadaily.com.cn/a/202101/06/AP5ff5600da310f03332f92bf0.html

 

(14) Qiwei Zhang*, Yiqiang Li, Pascal Fender, Bin Yu, Liqiang Feng, Ling Chen and Xianghui Yu*. Editorial: Adenoviral Infection and Immunity, and Adenoviral Vectors for Gene Therapy Applications. Frontiers in Microbiology.  2022, 13: 869059. (生物学二区,Top期刊) 

      https://www.frontiersin.org/article/10.3389/fmicb.2022.869059 

 

(15) Qiwei Zhang*, Shuping Jing, Zetao Cheng, Zhiwu Yu, Shoaleh Dehghan, Amirhossein Shamsaddini, Yuqian Yan, Min Li, and Donald Seto*. Comparative Genomic Analysis of Two Emergent Human Adenovirus Type 14 Respiratory Pathogen Isolates in China Reveals Similar yet Divergent Genomes. Emerging Microbes & Infections, 2017, 6, e93. (医学二区,IF: 19.568) https://mp.weixin.qq.com/s/mmFqCD8VxFhh2No7IEwq6g 

 

(16) Qiwei Zhang*, Seto D, Zhao S, Zhu L, Zhao W, Wan C*. Genome Sequence of the First Human Adenovirus Type 14 Isolated in China.  Journal of Virology, 2012, 86(12): 7019-7020(医学二区,IF: 5.103, Top期刊

 

(17) Qiwei Zhang*, Donald Seto, Bin Cao, Suhui Zhao, and Chengsong Wan*. Genome Sequence of Human Adenovirus Type 55, a Re-Emergent Acute Respiratory Disease Pathogen in China.  Journal of Virology, 201286(22)12441-12442(医学二区,Top期刊IF: 5.103

 

(18) Donald Seto, Chodosh J, Brister JR, Jones MS, Members of the Adenovirus Research Community (Qi-Wei Zhang et al). Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses. Journal of Virology, 2011, 85(11): 5701-5702. (医学二区,Top期刊IF: 5.103.

 

(19) Wei Tang, Yueyue Li, Qiaoyun Song, Ziqin Wang, Manmei Li, Qiwei Zhang, Ying Wang, Wencai Ye and Yaolan Li. Mechanism of Cross-Resistance to Fusion Inhibitors Conferred by the K394R Mutation in Respiratory Syncytial Virus Fusion Protein. Journal of Virology. 2021, 95(20): e0120521. (医学二区,Top期刊)

 

(20) Ashrafali M. Ismail1#, Tiange Cui#, Kalpana Dommaraju, Gurdeep Singh, Shoaleh Dehghan, Jason Seto, Susmita Shrivastava, Nadia B. Fedorova, Neha Gupta, Timothy B. Stockwell, Ramana Madupu, Albert Heim, Adriana E. Kajon, Eric G. Romanowski, Regis P. Kowalski, Jambulingam Malathi, Kuzhanthai L. Therese, Hajib Narahari Madhavan, Qiwei Zhang, Leonardo J. Ferreyra, Morris S. Jones, Jaya Rajaiya, David W. Dyer, James Chodosh*, and Donald Seto*. Genomic analysis of a large set of currently  and historically  important human adenovirus pathogens. Emerging Microbes & Infections, 2018, 7(1): 10. (医学二区,IF: 19.568)

 

(21) Tie Zhao, Chunhui Wang, Biyan Duan, Peipei Yang, Jianguo Wu* and Qiwei Zhang*. Altered Lipid Profile in COVID-19 Patients and Metabolic Reprogramming. Frontiers in Microbiology.  2022, 13: 863802. (生物学二区,Top期刊)

 

(22) Tie Zhao, Yi Ren, Jianguo Wu* and Qiwei Zhang*. Possible Mechanism of SARS-CoV-2 Nsp1-Mediated Control of Viral Gene Expression. Frontiers in Cellular and Infection Microbiology.  2022, 12: 881749.

 

(23) Pin Wan, Simeng Zhang, Zhihui Ruan, Xueli Liu, Ge Yang, Yaling Jia, Yongkui Li, Pan Pan, Wenbiao Wang, Geng Li, Xulin Chen, Zhixin Liu, Qiwei Zhang*, Zhen Luo* and Jianguo Wu*. AP-1 signaling pathway promotes pro-IL-1beta transcription to facilitate NLRP3 inflammasome activation upon influenza A virus infection. Virulence.  2022, 13(1): 502-513.

 

(24) Xiaojing Wen, Li Zhang, Shan Zhao, Qiang Liu, Wenyi Guan, Jiajing Wu, Qiwei Zhang*, Hongling Wen* and Weijin Huang*. High-Throughput Screening and Identification of Human Adenovirus Type 5 Inhibitors. Frontiers in Cellular and Infection Microbiology. 2021, 11: 10.3389/fcimb.2021.767578. (医学二区,IF5.293

 

(25) Wenyi Guan, Wendong Lan, Jing Zhang, Shan Zhao, Junxian Ou, Xiaowei Wu, Yuqian Yan, Jianguo Wu and Qiwei Zhang*. COVID-19: Antiviral Agents, Antibody Development and Traditional Chinese Medicine. Virologica Sinica.  2020: 10.1007/s12250-12020-00297-12250. (医学二区,IF6.947

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(26) Shan Zhao, Wenyi Guan, Kui Ma, Yuqian Yan, Junxian Ou, Jing Zhang, Zhiwu Yu, Jianguo Wu and Qiwei Zhang*. Development and Application of a Fast Method to Acquire the Accurate Whole-Genome Sequences of Human Adenoviruses. Frontiers in Microbiology.  2021, 12: 661382. (生物学二区,Top期刊IF: 6.064)         https://mp.weixin.qq.com/s/4DZrdIERFP_h6b2vuwjo-w 

 

(27) Hongying Fan, Zhenhui Chen, Ruqin Lin, Yangyang Liu, Xianbo Wu, Santhosh Puthiyakunnon, Ye Wang, Bo Zhu, Qiwei Zhang*, Yang Bai* and Fachao Zhi*. Bacteroides fragilis Strain ZY-312 Defense against Cronobacter sakazakii-Induced Necrotizing Enterocolitis In Vitro and in a Neonatal Rat Model. mSystems.  2019, 4(4): e00305-00319. (医学二区,IF: 6.496

 

(28) Yuqian Yan, Junxian Ou, Shan Zhao, Kui Ma, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jing Zhang, Bao Zhang, Wei Zhao, Chengsong Wan, Weifeng Shi, Jianguo Wu, Donald Seto, Zhiwu Yu* and Qiwei Zhang*. Characterization of Influenza A and B Viruses Circulating in Southern China During the 2017–2018 Season. Frontiers in Microbiology. 2020, 11(1079): 10.3389/fmicb.2020.01079. (生物学二区,Top期刊IF: 5.64

 

(29) Zetao Cheng#, Yuqian Yan#, Shuping Jing, Wen-Gang Li, Wei-Wei Chen, Jing Zhang, Min Li, Shan Zhao, Na Cao, Junxian Ou, Suhui Zhao, Xianbo Wu*, Bin Cao*, Qiwei Zhang*. Comparative Genomic Analysis of Re-emergent Human Adenovirus Type 55 Pathogens Associated With Adult Severe Community-Acquired Pneumonia Reveals Conserved Genomes and Capsid Proteins. Frontiers in Microbiology, 2018, 9(1180). 生物学二区,Top期刊IF: 5.64https://mp.weixin.qq.com/s/B-dq-f59FgNvsJlHzKOiXQ 

 

(30) Jing Zhang, Kui Ma, Xiangyu Wang, Yinbo Jiang, Shan Zhao, Junxian Ou, Wendong Lan, Wenyi Guan, Xiaowei Wu, Heping Zheng, Bin Yang, Chengsong Wan, Wei Zhao, Jianguo Wu* and Qiwei Zhang*. Desmoglein 2 (DSG2) is a Receptor of Human Adenovirus Type 55 Causing Adult Severe Community-Acquired Pneumonia. Virologica Sinica. 2021, 36(3). DOI: 10.1007/s12250-021-00414-7(医学二区,IF6.947

 

(31) Jing Zhang, June Kang, Shoaleh Dehghan, Siddharth Sridhar, Susanna Lau, Junxian Ou, Patrick Woo, Qiwei Zhang*, Donald Seto*. A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations. Viruses, 2019, 11(2):129. (医学二区,IF5.048http://m6z.cn/5B0s7B 

 

(32) Haibin Pan, Yuqian Yan, Jing Zhang, Shan Zhao, Liqiang Feng, Junxian Ou, Na Cao, Min Li, Wei Zhao, Chengsong Wan, Ashrafali M Ismail, Jaya Rajaiya, James Chodosh, Qiwei Zhang*. Rapid Construction of a Replication-Competent Infectious Clone of Human Adenovirus Type 14 by Gibson Assembly. Viruses, 2018, 10(10):568. 医学二区,IF5.048https://mp.weixin.qq.com/s/pOAjdDbLK45EY7quxFoKIw 

 

(33) Qiwei Zhang, Su X, Seto D, Zheng B-j, Tian X, Sheng H, Li H, Wang Y, Zhou R*. Construction and characterization of a replication-competent human adenovirus type 3-based vector as a live-vaccine candidate and a viral delivery vector.  Vaccine, 2009, 27(8): 1145-1153.  (医学二区,Top期刊IF:3.485)

 

(34) Yuqian Yan, Shuping Jing, Liqiang Feng, Jing Zhang, Zhiwei Zeng, Min Li, Shan Zhao, Junxian Ou, Wendong Lan, Wenyi Guan, Xiaowei Wu, Jianguo Wu, Donald Seto and Qiwei Zhang*. Construction and Characterization of a Novel Recombinant Attenuated and Replication-Deficient Candidate Human Adenovirus Type 3 Vaccine: “Adenovirus Vaccine Within an Adenovirus Vector”. Virologica Sinica.  202136(3): 354-364. (医学二区,IF6.947https://mp.weixin.qq.com/s/H0hsYKmfJSiMPlzEIF1_IQ 

 

(35) Qiwei Zhang, Su X, Gong S, Zeng Q, Zhu B, Wu Z, Peng T, Zhang C, Zhou R. Comparative genomic analysis of two strains of human adenovirus type 3 isolated from children with acute respiratory infection in southern China.  Journal of General Virology 2006, 87(6): 1531-1541.  (IF:3.529)

 

(36) Qiwei Zhang*, Shoaleh Dehghan, Donald Seto. Pitfalls of restriction enzyme analysis in identifying, characterizing, typing, and naming viral pathogens in the era of whole genome data, as illustrated by HAdV type 55. Virologica Sinica, 2016, 31(5):448-453. (医学二区,IF6.947

 

(37) Guiyuan Han, Hongling Niu, Suhui Zhao, Bing Zhu, Changbing, Wang, Yungang Liu, Mingjie Zhang, Shu Yang, Feitong Liu, Chengsong Wan, Qiwei Zhang*. Identification and typing of respiratory adenoviruses in Guangzhou, Southern China using a rapid and simple method. Virologica Sinica, 2013, 28(2):103-108. (医学二区,IF6.947

 

(38) Zhiwu Yu, Zhiwei Zeng, Jing Zhang, Yuxian Pan, Manjun Chen, Yonghui Guo, Nan Yu, James Chodosh, Ning Fu, Xiaoyan Che & Qiwei Zhang*. Fatal Community-acquired Pneumonia in Children Caused by Re-emergent Human Adenovirus 7d Associated with Higher Severity of Illness and Fatality Rate.  Scientific Reports, 2016, 6:37216. IF: 4.259

 

(39) Suhui Zhao, Chengsong Wan, Changwen Ke, Jason Seto, Shoaleh Dehghan, Lirong Zou, Jie Zhou, Zetao Cheng, Shuping Jing, Zhiwei Zeng, Jing Zhang, Xuan Wan, Xianbo Wu, Wei Zhao, Li Zhu, Donald Seto*, Qiwei Zhang*. Re-emergent Human Adenovirus Genome Type 7d Caused an Acute Respiratory Disease Outbreak in Southern China After a Twenty-one Year Absence.  Scientific Reports, 2014(4): 7365DOI: 10.1038/srep07365. (IF: 4.259)

 

(40) Zhiwei Zeng, Jing Zhang, Shuping Jing, Zetao Cheng, Silvia Bofill-Mas, Carlos Maluquer de Motes, Ayalkibet Hundesa, Rosina Girones, Donald Seto*, Qiwei Zhang*. Genome Sequence of a Cynomolgus Macaque Adenovirus (CynAdV-1) Isolate from a Primate Colony in the United Kingdom. Genome Announcements. 2016, 4(6): e01193-01116.

 

(41) Xiangyu Wang, Qi Sun, Zhonghua Ye, Ying Hua, Na Shao, Yanli Du, Qiwei Zhang*, Chengsong Wan*. Computational approach for predicting the conserved B-cell epitopes of hemagglutinin H7 subtype influenza virus. Experimental and Therapeutic Medicine, 2016, 12(4): 2439-2446. IF: 1.448


(42) Yi Chen, Fanghua Liu, Changbing Wang, Mingqi Zhao, Li Deng, Jiayu Zhong, Yingying Zhang, Jun Ye, Shuping Jing, Zetao Cheng, Yongxin Guan, Yi Ma, Yuanyuan Sun, Bing Zhu*, Qiwei Zhang*. Molecular Identification and Epidemiological Features of Human Adenoviruses Associated with Acute Respiratory Infections in Hospitalized Children in Southern China, 2012-2013. PLoS ONE, 2016, 11(5): e0155412. (IF:3.0)

 

(43) Qiwei Zhang*, Xiaomin Zhang, Hao Wu, Donald Seto, Hao-Jie Zhang, Zhiwei Chen, Chengsong Wan and Bo-Jian Zheng*. Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC.  PLoS ONE, 2012, 7: e31233. (IF:3.0)


(44) Suhui Zhao, Ying Zhou, Chunhui Wang, Yu Yang, Xianbo Wu, Yao Wei, Li Zhu, Wei Zhao, Qiwei Zhang*, Chengsong Wan*. The N-Terminal Domain of EspF Induces Host Cell Apoptosis after Infection with Enterohaemorrhagic Escherichia coli O157:H7. PLoS ONE 2013, 8(1):e55164. (IF:3.0)

 

(45) Xiangyu Wang, Zhonglu Ren, Qi Sun, Xuan Wan, Yaqing Sun, Ying Hua, Muqing Fu, Na Shao, Yanli Du, Chengsong Wan*, Qiwei Zhang*. Evaluation and comparison of newly built linear B-cell epitope prediction software from a users’ perspective. Current Bioinformatics, 2017,12:DOI: 10.2174/1574893612666170711154318 (IF:1.189)

 

(46) Hong-Ling Jia, Peng Li, Hong-Jie Liu, Jia-Yong Zhong, Peng-Zhe Qin, Wen-Zhe Su, Ying-Feng Zheng, Kui-Biao Li, Qing Zeng, Jin-Hui Li, Li-Zhong Li, Lan Cao, Ji-Bin Wu, Yi-Yun Chen, Lei-Li Jia, Hong-Bin Song, Qi-Wei Zhang, Guang Yang, Chun-Xia Jing, Xiao-Chen Bo, Zhou-Bin Zhang, Biao Di, Chuan-Le Xiao and Ming Ni. Genomic Elucidation of a COVID-19 Resurgence and Local Transmission of SARS-CoV-2 in Guangzhou, China. Journal of Clinical Microbiology.  2021, 59(8): e0007921. Top期刊,IF11.677

 

(47) Jian Shang, Yuan Zheng, Jiayin Mo, Wenbiao Wang, Zhen Luo, Yongkui Li, Xulin Chen, Qiwei Zhang, Kailang Wu, Weiyong Liu, Jianguo Wu*. Sox4 represses host innate immunity to facilitate pathogen infection by hijacking the TLR signaling networks. Virulence, 2021, 12(1):704-722.  (IF: 5.5)

 

(48) Xiao-Min Zhang, Hao Wu, Qiwei Zhang, Terrence Chi-Kong Lau, Hin Chu, Zhi-Wei Chen, Dong-Yan Jin and Bo-Jian Zheng. A novel mutation, D404N, in the connection subdomain of reverse transcriptase of HIV-1 CRF08_BC subtype confers cross-resistance to NNRTIs. Journal of Antimicrobial Chemotherapy, 2015, 70(5): 1381-90. (药学一区,Top期刊IF: 5.439)

 

(49) Tingting Chen, Xiaoen He, Peiru Zhang, Yawen Yuan, Xinyue Lang, Jianhai Yu, Zhiran Qin, Xujuan Li, Qiwei Zhang, Li Zhu, Bao Zhang, Qinghua Wu and Wei Zhao. Research advancements in the neurological presentation of flaviviruses. Reviews in Medical Virology.  2019, 29(1): e2021. (医学二区,IF:5.034)

 

(50) T. Huang, J. Yang, J. Zhang, W. Ke, F. Zou, C. Wan, L. Wang, X. Zhang, F. Liang, S. Mei, Q. Zhang, Z. Rong, B. Yang* and H. Zheng*. MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum-Stimulated Macrophages. Journal of Investigative Dermatology.  2020, 140(8): 1566-1575 e1561. (皮肤病学一区IF: 8.551, Top期刊)

 

(51) T. Huang, J. Zhang, W. J. Ke, X. H. Zhang, W. T. Chen, J. Y. Yang, Y. W. Liao, F. W. Liang, S. Q. Mei, M. J. Li, Z. Z. Luo, Q.W. Zhang, B. Yang and H. P. Zheng. MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis. BMC Infectious Diseases.  2020, 20(1): 165.

 

(52) Jianhai Yu, Xuling Liu, Changwen Ke, Qinghua Wu, Weizhi Lu, Zhiran Qin, Xiaoen He, Yujing Liu, Jieli Deng, Suiqi Xu, Ying Li, Li Zhu, Chengsong Wan, Qiwei Zhang, Weiwei Xiao, Qian Xie, Bao Zhang*, Wei Zhao*. Effective Suckling C57BL/6, Kunming, and BALB/c Mouse Models with Remarkable Neurological Manifestation for Zika Virus Infection. Viruses, 2017, 9(7):165. (医学二区,IF: 5)

 

(53) Xiangyu Wang, Yanli Du, Ying Hua, Muqing Fu, Cong Niu, Bao Zhang, Wei Zhao, Qiwei Zhang, Chengsong Wan. The EspF N-Terminal of Enterohemorrhagic Escherichia coli O157:H7 EDL933w Imparts Stronger Toxicity Effects on HT-29 Cells than the C-Terminal. Frontiers in Cellular and Infection Microbiology, 2017, 7(410): 10.3389/fcimb.2017.00410. (医学二区,IF: 5.293)

 

(54) Li H, Zhou R, Chen J, Tian X, Zhang Qiwei, Zeng Q, Gong S. A recombinant replication-defective human adenovirus type 3: A vaccine candidate. Vaccine 2009, 27(1): 116-122.  (医学二区,Top期刊,IF: 3.485)

 

(55) Seto, J., Walsh, M., Mahadevan, P., Zhang Qiwei. & Seto, D. Applying Genomic and Bioinformatic Resources to Human Adenovirus Genomes for Use in Vaccine Development and for Applications in Vector Development for Gene Delivery. Viruses 2010, 2(1):1-26.  (医学二区,IF: 5

 

(56) Ying Hua, Jingwei Ju, Xiangyu Wang, Bao Zhang, Wei Zhao, Qiwei Zhang, Yingzhu Feng, Wenbin Ma, Chengsong Wan. Screening for host proteins interacting with Escherichia coli O157:H7 EspF using bimolecular fluorescence complementation. Future Microbiology, 2017, 13(1):3758. (IF: 3.374)

 

(57) W. W. Xiao, W. Zhao, L. Li, Q. H. Wu, L. Zhu, Q. W. Zhang, W. P. Dai, Y. Wang and B. Zhang. Preliminary investigation of the role of BTB domain-containing 3 gene in the proliferation and metastasis of hepatocellular carcinoma. Oncol Lett.  2017, 14(2): 2505-2510.

 

(58) Niittykoski M, von Und Zu Fraunberg M, Martikainen M, Rauramaa T, Immonen A, Koponen S, Leinonen V, Vaha-Koskela M, Zhang Qiwei, Kuhnel F, Mei YF, Yla-Herttuala S, Jaaskelainen JE, Hinkkanen A. Immunohistochemical Characterization and Sensitivity to Human Adenovirus Serotypes 3, 5, and 11p of New Cell Lines Derived from Human Diffuse Grade II to IV Gliomas. Transl Oncol, 2017, 10(5):772-779. (IF: 3.025)

 

(59) Xiao-Min Zhang, Qiwei Zhang, Hao Wu, Terrence Chi-Kong Lau, Xuan Liu, Hin Chu, Ke Zhang, Jie Zhou, Zhiwei Chen, Dong-Yan Jin, Bo-Jian Zheng. Novel Mutations L228i and Y232h Cause Nnrti Resistance in Combinational Pattern. AIDS Res Hum Retroviruses, 2016: 32(9): 909-917.

 

(60) Hao Wu, Xiaomin Zhang, Haojie Zhang, Qiwei Zhang, Zhiwei Chen, Jiandong Huang, Shui-Shan Lee, Bo-Jian Zheng. In Vitro Selection of Hiv-1 Crf08_Bc Variants Resistant to Reverse Transcriptase Inhibitors. AIDS Res Hum Retroviruses, 2015312):260-270


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